BP102T. PHARMACEUTICAL ANALYSIS Books
“Exploring the principles and techniques of pharmaceutical analysis, including analytical methods and instruments to identify, separate, and quantify pharmaceutical substances, ensuring quality and regulatory compliance.”
Course Content
Unit Title
Content
UNIT-1
- Pharmaceutical analysis- Definition and scope
i) Different techniques of analysis
ii) Methods of expressing concentration
iii) Primary and secondary standards.
iv) Preparation and standardization of various molar and normal solutions
Oxalic acid, sodium hydroxide, hydrochloric acid, sodium thiosulphate,
sulphuric acid, potassium permanganate and ceric ammonium sulphate - Errors: Sources of errors, types of errors, methods of minimizing errors,
accuracy, precision and significant figures - Pharmacopoeia: Sources of impurities in medicinal agents,limit tests.
UNIT-2
- Acid base titration: Theories of acid base indicators, classification of
acid base titrations and theory involved in titrations of strong, weak, and very weak acids and bases, neutralization curves - Non aqueous titration: Solvents, acidimetry and alkalimetry titration and estimation of Sodium benzoate and Ephedrine HC
UNIT-3
- Precipitation titrations:
Mohr’s method, Volhard’s, Modified Volhard’s, Fajans method, estimation of sodium chloride. - Complexometric titration: Classification, metal ion indicators, masking
and demasking reagents, estimation of Magnesium sulphate, and calcium gluconate. - Gravimetry: Principle and steps involved in gravimetric analysis. Purity
of the precipitate: co-precipitation and post precipitation, Estimation of
barium sulphate.
Basic Principles,methods and application of diazotisation titration
UNIT-4
- Redox titration
(a) Concepts of oxidation and reduction
(b) Types of redox titrations (Principles and applications)
Cerimetry, Iodimetry, Iodometry, Bromatometry, Dichrometry, Titration with
potassium iodate
UNIT-5
- Electrochemical methods of analysis
- Conductometry- Introduction, Conductivity cell, Conductometric
titrations, applications. - Potentiometry- Electrochemical cell, construction and working of reference (Standard hydrogen, silver chloride electrode and
calomel electrode) and indicator electrodes (metal electrodes and
glass electrode), methods to determine end point of potentiometric
titration and applications. - Polarography- Principle, Ilkovic equation, construction and
working of dropping mercury electrode and rotating platinum
electrode, application
Learning Objectives
- Develop analytical skills
- Carry out various volumetric and electrochemical titrations
- Understand the principles of volumetric and electro chemical analysis
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