BP301T. PHARMACEUTICAL ORGANIC CHEMISTRY –II Books
Pharmaceutical Organic Chemistry II: Advanced study of the design, synthesis, and analysis of complex organic molecules for medicinal purposes, focusing on drug development and optimizatio
Course Content
Unit Title
Content
UNIT-I
- Benzene & its derivatives
- A. Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic
characters, Huckel’s rule - B. Reactions of benzene- nitration, sulphonation, halogenation
reactivity, Friedel crafts alkylation reactivity, limitations, Friedel crafts acylation. - C. Substituents, effect of substituents on reactivity and orientation of
mono substituted benzene compounds towards electrophilic
substitution reaction - D. Structure and uses of DDT, Saccharin, BHC and Chloramine
UNIT-II
- Phenols- Acidity of phenols, effect of substituents on acidity, qualitative
tests, Structure and uses of phenol, cresols, resorcinol, naphthol - Aromatic amines- Basicity of amines, effect of substituents on basicity,and synthetic uses of aryl diazonium salts
- Aromatic acids- –Acidity, effect of substituents on acidity and
important reactions of benzoic acid.
UNIT-III
- Fats & oils-
- a. Fattyacids– reactions.
- b. Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying
oils. - c. Analytical constants– Acid value, Saponification value, Ester value,
Iodine value, Acetyl value, Reichert Meissl (RM) value– significance and
principle involved in their determination
UNIT-IV
- Polynuclear hydrocarbons- a. Synthesis, reactions
b. Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivative
UNIT-IV
- Cycloalkanes- Stabilities– Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only
Learning Objectives
- write the structure, name and the type of isomerism of the organic compound
- write the reaction, name the reaction and orientation of reactions
- Account for reactivity/stability of compounds,
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