BP404T. PHARMACOLOGY-I Books
Pharmacology I: Study of drug actions, interactions, and effects on the body, covering pharmacokinetics, pharmacodynamics, and major organ systems.
Course Content
Unit Title
Content
UNIT-I
- General pharmacology- Introduction to Pharmacology- Definition, historical landmarks and scope of
pharmacology, nature and source of drugs, essential drugs concept and routes of drug administration, Agonists, antagonists( competitive and non competitive), spare receptors, addiction, tolerance, dependence, tachyphylaxis, idiosyncrasy, allergy. - b. Pharmacokinetics- Membrane transport, absorption, distribution, metabolism and excretion of drugs .Enzyme induction, enzyme inhibition, kinetics of elimination
UNIT-II
- General pharmacology- Pharmacodynamics- Pharmacodynamics- Principles and mechanisms of drug action. Receptor theories
and classification of receptors, regulation of receptors. drug receptors interactions signal transduction mechanisms, G-protein–coupled receptors, ion channel receptor, transmembrane enzyme linked receptors, transmembrane JAK-STAT binding
receptor and receptors that regulate transcription factors, dose response relationship, therapeutic index, combined effects of drugs and factors modifying drug action. - Adverse drug reactions
- Drug interaction
- Drug discover & evaluation of new drugs
UNIT-III
- Pharmacology of drugs acting on peripheral nervous system
- a. Organization and function of ANS.
- b.Neurohumoral transmission,co-transmission and classification of neurotransmitters.
- c. Parasympathomimetics, Parasympatholytics, Sympathomimetics, sympatholytics.
- d. Neuromuscular blocking agents and skeletal muscle relaxants (peripheral).
- e. Local anesthetic agents.
- f. Drugs used in myasthenia gravis and glaucoma
UNIT-IV
- Pharmacology of drugs acting on central nervous system
- a. Neurohumoral transmission in the C.N.S.special emphasis on importance of various
neurotransmitters like with GABA, Glutamate, Glycine, serotonin, dopamine. - b. General anesthetics and pre-anesthetics.
- c. Sedatives, hypnotics and centrally acting muscle relaxants.
- d. Anti-epileptics
- e. Alcohols and disulfiram
UNIT-V
- Pharmacology of drugs acting on central nervous system
- a. Psychopharmacological agents: Antipsychotics, antidepressants, anti-anxiety agents,
anti-manics and hallucinogens. - b. Drugs used in Parkinsons disease and Alzheimer’s disease.
- c. CNS stimulants and nootropics.
- d. Opioid analgesics and antagonists
- e. Drug addiction, drug abuse, tolerance and dependence.
Learning Objectives
- Understand the pharmacological actions of different categories of drugs
- Explain the mechanism of drug action at organ system/sub cellular/ macromolecular levels.
- Apply the basic pharmacological knowledge in the prevention and treatment of various diseases.
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