BP704T. NOVEL DRUG DELIVERY SYSTEMS (NDDS) Books
“Novel Drug Delivery System: Innovative approaches to delivering drugs, including:
– Targeted delivery
– Controlled release
– Nanotechnology-based systems
– Advanced formulation technologies
Course Content
Unit Title
Content
UNIT-I
- Controlled drug delivery systems: Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates.Approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and biological properties of drugs relevant to controlled release formulations
- Polymers: Introduction, classification, properties, advantages and application of polymers in formulation of controlled release drug delivery systems
UNIT-II
- Microencapsulation: Definition, advantages and disadvantages, microspheres /microcapsules, microparticles, methods of microencapsulation, applications
- Mucosal Drug Delivery system: Introduction, Principles of bioadhesion /
mucoadhesion, concepts, advantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems - Implantable Drug Delivery Systems:Introduction, advantages and disadvantages, concept of implants and osmotic pump
UNIT-III
- Transdermal Drug Delivery Systems: Introduction, Permeation through skin, factors affecting permeation, permeation enhancers, basic components of TDDS, formulation approaches
- Gastroretentive drug delivery systems: Introduction, advantages, disadvantages, approaches for GRDDS – Floating, high density systems, inflatable and gastroadhesive systems and their applications
- Nasopulmonary drug delivery system: Introduction to Nasal and Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers
UNIT-IV
- Targeted drug Delivery: Concepts and approaches advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications
UNIT-V
- Ocular Drug Delivery Systems: Introduction, intra ocular barriers and methods to overcome –Preliminary study, ocular formulations and ocuserts
- Intrauterine Drug Delivery Systems: Introduction, advantages and disadvantages, development of intra uterine devices (IUDs) and applications
Learning Objectives
- To understand various approaches for development of novel drug delivery systems
- To understand the criteria for selection of drugs and polymers for the development of Novel drug delivery systems, their formulation and evaluation
Share on WhatsApp