Disease Related

TOLAZOLINE

Tolazoline is a medication used as a vasodilator to manage conditions such as pulmonary hypertension and peripheral vascular disorders. It works by relaxing the smooth muscles in blood vessels, leading to vasodilation and improved blood flow. Tolazoline is often administered intravenously in a hospital setting and is utilized to help reduce elevated blood pressure in the lungs and improve circulation. Its use requires careful monitoring to manage potential side effects like hypotension or fluid retention.

Tolazoline is a medication that belongs to the class of alpha-adrenergic blockers. Here is a detailed description:

Chemical Name: 2-Benzyl-4,5-dihydro-1H-imidazole

Molecular Formula: C10H12N2

Mechanism of Action:

  • Tolazoline works by blocking alpha-adrenergic receptors, causing blood vessels to dilate and increasing blood flow.

Indications:

  • Peripheral vascular disease
  • Raynaud’s disease
  • Erectile dysfunction
  • Neonatal hypertension

Pharmacokinetics:

  • Absorption: Well absorbed after oral administration
  • Distribution: Widely distributed throughout the body
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted in the urine

Side Effects:

  • Headache
  • Dizziness
  • Nausea and vomiting
  • Flushing
  • Hypotension

Contraindications:

  • Hypersensitivity to Tolazoline
  • Severe coronary artery disease
  • Heart failure
  • Glaucoma

Dosage: avoid self medication

  • Oral: 25-50 mg, every 6-8 hours
  • Intravenous: 1-2 mg/kg, every 6-8 hours

Forms:

  • Tablets
  • Injection

Please note that this information is not a substitute for medical advice. If you have any questions or concerns about Tolazoline or any other medication, please consult a healthcare professional.