Disease Related

METHYSERGIDE

Methysergide is a medication used for the prevention of migraine and cluster headaches. It is an ergot derivative that works as a serotonin receptor antagonist, helping to reduce the frequency and severity of headache attacks. Methysergide is typically administered orally in tablet form and is often used as a long-term preventive treatment. Common side effects can include gastrointestinal issues, dizziness, or fatigue, and it is important to use it under medical supervision due to potential risks, including fibrosis or vascular complications with prolonged use.

Methysergide is a medication that belongs to the class of ergot alkaloids. Here is a detailed description:

Chemical Name: 1-Methyl-lysergic acid butanolamide

Molecular Formula: C21H27N3O2

Mechanism of Action:

  • Methysergide works by blocking serotonin receptors, constricting blood vessels, and reducing inflammation.

Indications:

  • Migraine headaches (prophylaxis)
  • Cluster headaches (prophylaxis)

Pharmacokinetics:

  • Absorption: Well absorbed after oral administration
  • Distribution: Widely distributed throughout the body
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted in the urine

Side Effects:

  • Nausea and vomiting
  • Dizziness
  • Headache
  • Fatigue
  • Fibrotic reactions (rare)

Contraindications:

  • Hypersensitivity to Methysergide
  • Coronary artery disease
  • Heart failure
  • Liver disease
  • Pregnancy
  • History of fibrotic reactions

Dosage: avoid self medication

  • Oral: 2-8 mg, every 8-12 hours

Forms:

  • Tablets

Please note that this information is not a substitute for medical advice. If you have any questions or concerns about Methysergide or any other medication, please consult a healthcare professional.

Note: Methysergide is no longer available in the US due to rare but serious side effects, including fibrotic reactions. It is still available in some countries, but its use is strictly monitored.