M. Pharmacy Quiz-43

DEPTH OF BIOLOGY

Which of the following computational methods predicts protein structure by aligning a query sequence to known protein folds?

Homology modeling

Threading

Ab initio modeling

X-ray crystallography

Homology modeling relies on:

Random folding prediction

Experimental X-ray diffraction data

Known related protein structures (templates)

Energy minimization only

In NMR spectroscopy, the structure of a protein is determined by:

Measuring electron density in crystals

Detecting atomic distances via magnetic fields

Aligning with known protein templates

Using computer simulations

X-ray crystallography provides which type of protein structure?

Dynamic ensemble model

Static 3D model

Sequence-based prediction

Hybrid homology model

The primary difference between threading and homology modeling is that:

Threading uses experimental data; homology modeling does not

Threading compares to known folds; homology modeling uses known structures

Threading is faster but less accurate

Both methods are identical

M. Pharmacy Quiz-43

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