BP302T. PHYSICAL PHARMACEUTICS-I Books
Physical Pharmaceutics: Application of physical principles to study pharmaceutical systems, including drug substance characterization, phase behavior, and drug delivery, to develop effective and stable drug products.
Course Content
Unit Title
Content
UNIT-I
Solubility of drugs– Solubility expressions ,mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors influencing solubility of drugs, diffusion principles in biological systems .Solubility
of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law, real solutions. Partially miscible liquids, Critical solution temperature and applications. Distribution law, its limitations and applications
UNIT-II
States & properties of matter- State of matter ,changes in the state of matter, latent heats, vapour pressure, sublimation critical point ,eutectic mixtures, gases, aerosols–inhalers, relative humidity, liquid complexes, liquid crystals, glassy states, solid crystalline, amorphous& polymorphism
Physicochemical properties of drug molecules- Refractive index, optical rotation, dielectric constant, dipole moment, dissociation constant ,determinations and applications
UNIT-III
Surface & interfacial phenomenon- Liquid interface, surface & interfacial tensions, surface free energy ,measurement of surface & interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB Scale, solubilisation,
detergency, adsorption at solid interface
UNIT-IV
- Complexation & protein binding- Introduction, Classification of Complexation, Applications, methods of analysis, protein binding, Complexation and drug action, crystalline structures of complexes and thermodynamic treatment of stability constants.
UNIT-V
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pH, buffer & isotonic solution- Sorensen’s pH scale, pH determination
(electrometric and calorimetric), applications of buffers, buffer equation, buffer capacity, buffers in pharmaceutical and biological systems, buffered isotonic solutions.
Learning Objectives
- Understand various physicochemical properties of drug molecules in the designing the dosage forms
- Know the principles of chemical kinetics & to use them for stability testing & determination of expiry date of formulations
- Demonstrate use of physicochemical properties in the formulation development and evaluation of dosage forms.