BP401T. PHARMACEUTICAL ORGANIC CHEMISTRY-III Books
Organic Chemistry III: Advanced study of complex organic reactions, synthesis, and spectroscopy, focusing on advanced topics and intricate transformations..
Course Content
Unit Title
Content
UNIT-I
- Stereo isomerism
- Optical isomerism – Optical activity, enantiomerism, diastereoisomerism, meso compounds
- Elements of symmetry, chiral and achiral molecules
- DL system of nomenclature of optical isomers, sequence rules, RS system of nomenclature of optical isomers
- Reactions of chiral molecules
- Racemic modification and resolution of racemic mixture. Asymmetric synthesis: partial and absolute
UNIT-II
- Geometrical isomerism
- Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems)
Methods of determination of configuration of geometrical isomers. - Conformational isomerism in Ethane, n-Butane and Cyclohexane.
- Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity.
- Stereospecific and stereoselective reactions
UNIT-III
- Heterocyclic compounds:
- Nomenclature and classification
- Synthesis, reactions and medicinal uses of following compounds/derivatives
- Pyrrole, Furan, and Thiophene
- Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene
UNIT-IV
- Synthesis, reactions and medicinal uses of following compounds/derivatives
- Pyrazole, Imidazole, Oxazole and Thiazole.
Pyridine, Quinoline, Isoquinoline, Acridine and Indole. - Basicity of pyridine
- Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives
UNIT-V
- Reactions of synthetic importance
- Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction.
- Oppenauer-oxidation and Dakin reaction.
- Beckmanns rearrangement and Schmidt rearrangement.
- Claisen-Schmidt condensation
Learning Objectives
- understand the methods of preparation and properties of organic compounds
- explain the stereo chemical aspects of organic compounds and stereo chemical reactions
- know the medicinal uses and other applications of organic compounds
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