BP403T. PHYSICAL PHARMACEUTICS-II books
Physical Pharmaceutics II: Advanced application of physical principles to pharmaceutical systems, focusing on drug delivery, biopharmaceutics, and powder technology.
Course Content
Unit Title
Content
UNIT-I
- Colloidal dispersion- Classification of dispersed systems & their general characteristics, size & shapes of colloidal particles, classification of colloids & comparative account of their general properties. Optical, kinetic & electrical properties. Effect of electrolytes, coacervation, peptization& protective action.
UNIT-II
- Rheology- Newtonian systems, law of flow, kinematic viscosity, effect of temperature, non-Newtonian systems, pseudoplastic, dilatant, plastic, thixotropy, thixotropy in formulation, determination of viscosity, capillary, falling Sphere, rotational viscometers
- Deformation of solids- Plastic and elastic deformation, Heckel equation, Stress, Strain, Elastic Modulus
UNIT-III
- Coarse dispersion- Suspension, interfacial properties of suspended particles, settling in suspensions, formulation of flocculated and deflocculated suspensions. Emulsions and theories of emulsification, microemulsion and multiple emulsions; Stability of emulsions,
preservation of emulsions, rheological properties of emulsions and emulsion formulation by HLB method
UNIT-IV
- Micromeretics- Particle size and distribution, mean particle size, number and weight distribution, particle number, methods for determining particle size by different methods, counting and separation method, particle shape, specific surface, methods for
determining surface area, permeability, adsorption, derived properties of powders, porosity, packing arrangement, densities, bulkiness & flow properties.
UNIT-V
- Drug stability: Reaction kinetics: zero, pseudo-zero, first & second order, units of basic rate constants, determination of reaction order. Physical and chemical factors influencing the chemical degradation of pharmaceutical product: temperature, solvent, ionic strength, dielectric constant, specific & general acid base catalysis, Simple numerical problems. Stabilization of medicinal agents against common reactions like hydrolysis & oxidation. Accelerated stability testing in expiration dating of pharmaceutical dosage forms.
Photolytic degradation and its prevention
Learning Objectives
- Understand various physicochemical properties of drug molecules in the designing the dosage forms
- Know the principles of chemical kinetics & to use them for stability testing & determination of expiry date of formulations
- Demonstrate use of physicochemical properties in the formulation development and evaluation of dosage forms.
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