CLONIDINE

Clonidine is a medication used to treat high blood pressure and certain conditions like ADHD and withdrawal symptoms. It works by stimulating alpha-2 adrenergic receptors in the brain, which helps lower blood pressure and reduce symptoms by decreasing nerve signal transmission.

Chemical Name: N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine

Molecular Formula: C9H9Cl2N3

Mechanism of Action:

Clonidine works by stimulating alpha-2 adrenergic receptors in the brain, which reduces sympathetic nervous system activity, leading to:
- Decreased blood pressure
- Decreased heart rate
- Decreased peripheral vascular resistance

Indications:

High blood pressure (hypertension)
Attention deficit hyperactivity disorder (ADHD)
Pain management (especially neuropathic pain)
Anxiety disorders
Sleep disorders

Pharmacokinetics:

Absorption: Well absorbed after oral administration
Distribution: Widely distributed throughout the body
Metabolism: Metabolized in the liver
Excretion: Excreted in the urine

Side Effects:

Drowsiness
Dizziness
Dry mouth
Constipation
Headache
Fatigue
Sedation

Contraindications:

Hypersensitivity to Clonidine
Severe heart disease
Severe kidney disease
Pregnancy (first trimester)

Dosage: avoid self medication

Oral: 0.1-0.3 mg, 2-3 times a day
Transdermal patch: 0.1-0.3 mg, once a week

Forms:

Tablets
Injection
Transdermal patch

Please note that this information is not a substitute for medical advice. If you have any questions or concerns about Clonidine or any other medication, please consult a healthcare professional.