Disease Related

DIHYDROERGOTAMINE

Dihydroergotamine is a medication used primarily to treat acute migraine attacks and cluster headaches. It is an ergot alkaloid that works by constricting blood vessels in the brain and reducing inflammation, which helps alleviate headache symptoms. Dihydroergotamine is usually administered via nasal spray or injection. It is effective in managing severe headache episodes but can cause side effects such as nausea, dizziness, or muscle cramps. It should be used according to medical guidance to minimize potential complications.

Dihydroergotamine (DHE) is a medication that belongs to the class of ergot alkaloids. Here is a detailed description:

Chemical Name: 9,10-Dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)ergotaman-3′,6′,18-trione

Molecular Formula: C19H23N3O4

Mechanism of Action:

  • DHE works by constricting blood vessels, blocking pain pathways, and reducing inflammation.

Indications:

  • Migraine headaches
  • Cluster headaches
  • Chronic daily headaches

Pharmacokinetics:

  • Absorption: Well absorbed after intravenous, intramuscular, or nasal administration
  • Distribution: Widely distributed throughout the body
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted in the bile and urine

Side Effects:

  • Nausea and vomiting
  • Headache
  • Dizziness
  • Weakness
  • Nasal congestion

Contraindications:

  • Hypersensitivity to DHE
  • Coronary artery disease
  • Heart failure
  • Liver disease
  • Pregnancy

Dosage: avoid self medication

  • Intravenous: 1 mg, every 8 hours
  • Intramuscular: 1 mg, every 8 hours
  • Nasal spray: 1-2 sprays, every 15 minutes

Forms:

  • Injection
  • Nasal spray

Please note that this information is not a substitute for medical advice. If you have any questions or concerns about Dihydroergotamine or any other medication, please consult a healthcare professional.