LABETOLOL

Labetalol is a non-selective beta-blocker with additional alpha-1 blocking properties, used to treat hypertension and manage severe high blood pressure. It works by reducing heart rate and dilating blood vessels, which helps lower blood pressure. Labetalol can be administered orally or intravenously, often in emergency or hospital settings. Common side effects include dizziness, fatigue, and orthostatic hypotension. It should be used cautiously in patients with respiratory conditions, diabetes, or certain cardiovascular issues.

Chemical Name: 5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]salicylamide

Molecular Formula: C19H24N2O3

Mechanism of Action:

Labetalol works by blocking both alpha- and beta-adrenergic receptors, reducing blood pressure and heart rate.

Indications:

Hypertension (high blood pressure)
Severe hypertension (emergency situations)

Pharmacokinetics:

Absorption: Well absorbed after oral administration
Distribution: Widely distributed throughout the body
Metabolism: Metabolized in the liver
Excretion: Excreted in the urine

Side Effects:

Fatigue
Dizziness
Headache
Nausea and vomiting
Hypotension (low blood pressure)

Contraindications:

Hypersensitivity to Labetalol
Severe bradycardia
Heart block
Cardiogenic shock
Severe asthma
Pregnancy (caution)

Dosage: avoid self medication

Oral: 100-800 mg, every 12 hours
Intravenous: 20-80 mg, every 10-30 minutes

Forms:

Tablets
Injection

Please note that this information is not a substitute for medical advice. If you have any questions or concerns about Labetalol or any other medication, please consult a healthcare professional.