M. pharmacy quiz 30

DEPTH OF BIOLOGY

Which of the following is a characteristic of a non-linear compartment model?

First-order elimination at all concentrations

Dose-independent kinetics

Saturable processes like enzyme metabolism or active transport

Constant clearance regardless of dose

In a two-compartment linear model, compartment A usually represents:

Peripheral tissue compartment

Central compartment (plasma and highly perfused organs)

Storage tissues only

Sites of drug excretion

The rate constants (k1, k2, k3) in compartment models represent:

Drug concentration in the compartments

Transfer rate of drug between compartments or elimination

Clearance volume of drug

Bioavailability of the drug

Michaelis-Menten kinetics is typically associated with which model?

Linear one-compartment model

Open model with first-order elimination

Non-linear compartment model

Two-compartment linear model

A major limitation of non-linear compartment models is:

They require complex mathematical treatment due to dose-dependent kinetics

They are too simple for clinical use

They cannot describe drug distribution phases

They do not apply to any real drugs

M. pharmacy quiz 30

You got {{userScore}} out of {{maxScore}} correct