M. Pharmacy Quiz-50

DEPTH OF BIOLOGY

Which of the following best defines toxicokinetics?

Study of toxic effects at molecular level

Study of absorption, distribution, metabolism, and excretion (ADME) of toxic substances

Study of clinical manifestations of toxicity

Study of therapeutic drug monitoring

What is the main purpose of toxicokinetic evaluation in preclinical studies?

To determine the therapeutic efficacy of the drug

To identify potential drug-drug interactions

To understand the relationship between dose, systemic exposure, and toxicity

To estimate patient compliance

What does “saturation kinetics” in toxicokinetics refer to?

When the rate of metabolism increases linearly with dose

When elimination processes become saturated at high doses, , leading to non-linear kinetics

When absorption decreases with higher doses

When drug distribution becomes instantaneous

Which of the following represents the 3R principle in animal testing alternatives?

Replace, Repair, Recycle

Reuse, Reduce, Repeat

Replace, Reduce, Refine

Replace, React, Record

Which analytical technique is commonly used to quantify drug concentrations in toxicokinetic studies?

High-Performance Liquid Chromatography (HPLC)

ELISA

NMR Spectroscopy

Mass Balance Studies

M. Pharmacy Quiz-50

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