M. Pharmacy Quiz-8

The cellular response to thyroid hormone binding involves which of the following events?

Increased cAMP levels

DNA binding and mRNA transcription

Protein phosphorylation

Opening of calcium channels

Which of the following is a non-radioactive iodine compound used to acutely inhibit thyroid hormone release?

Potassium iodide (KI)

Radioiodine (I-131)

Methimazole

Levothyroxine

What is the primary site of action of the antithyroid drug methimazole?

At the nuclear receptor level

At the level of iodide uptake

On thyroid peroxidase enzyme

On thyroxine-binding globulin

Which enzyme is inhibited by antithyroid drug propylthiouracil (PTU)?

Thyroglobulin synthetase

Thyroid peroxidase

Monoamine oxidase

Na⁺/K⁺ ATPase

Which of the following is the primary mechanism of action of thyroid hormones (T3 and T4)?

Activation of G-protein coupled receptors

Binding to nuclear receptors and modulating gene transcription

Inhibition of adenylate cyclase

Direct activation of ion channels

M. Pharmacy Quiz-8

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