Disease Related

METHYLDOPA

Methyldopa is a medication primarily used to treat high blood pressure (hypertension). It works by stimulating alpha-2 adrenergic receptors in the brain, which helps lower blood pressure by reducing the amount of adrenaline and other stress hormones.

Methyldopa is a medication used to treat high blood pressure (hypertension). Here is a detailed description:

Chemical Name: (S)-2-Amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid

Molecular Formula: C10H13NO4

Mechanism of Action:

  • Methyldopa works by stimulating alpha-adrenergic receptors in the brain, which reduces sympathetic nervous system activity, leading to decreased blood pressure.

Indications:

  • High blood pressure (hypertension)
  • Pregnancy-induced hypertension
  • Preeclampsia

Pharmacokinetics:

  • Absorption: Well absorbed after oral administration
  • Distribution: Widely distributed throughout the body
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted in the urine

Side Effects:

  • Drowsiness
  • Dizziness
  • Headache
  • Fatigue
  • Nausea
  • Diarrhea
  • Increased liver enzymes

Contraindications:

  • Hypersensitivity to Methyldopa
  • Active liver disease
  • Severe kidney disease
  • Pregnancy (first trimester)

Dosage: avoid self medication

  • Oral: 250-500 mg, 2-3 times a day
  • Injection: 250-500 mg, every 6-8 hours

Forms:

  • Tablets
  • Injection

Please note that this information is not a substitute for medical advice. If you have any questions or concerns about Methyldopa or any other medication, please consult a healthcare professional.