Disease Related

NOR-EPINEPHRINE

Norepinephrine is a neurotransmitter and hormone crucial for the body’s “fight or flight” response. It helps regulate mood, alertness, and stress levels by increasing heart rate, blood pressure, and blood sugar. In the brain, norepinephrine influences attention and arousal, while in the peripheral nervous system, it prepares the body to react to perceived threats

Norepinephrine is a medication and a naturally occurring chemical in the body.

Chemical Name: (R)-4-(2-amino-1-hydroxyethyl)benzene-1,2-diol

Molecular Formula: C8H11NO3

Mechanism of Action:

  • As a medication, norepinephrine works by constricting blood vessels and increasing blood pressure.
  • As a neurotransmitter, norepinephrine plays a role in attention, arousal, and stress response.

Indications:

  • Medication:
    • Hypotension (low blood pressure)
    • Septic shock
    • Cardiac arrest
  • Neurotransmitter:
    • Attention and focus
    • Arousal and wakefulness
    • Stress response

Pharmacokinetics:

  • Absorption: Rapidly absorbed after injection
  • Distribution: Widely distributed throughout the body
  • Metabolism: Metabolized by monoamine oxidase (MAO)
  • Excretion: Excreted in the urine

Side Effects:

  • Hypertension (high blood pressure)
  • Tachycardia (rapid heart rate)
  • Arrhythmias (abnormal heart rhythms)
  • Anxiety
  • Insomnia

Contraindications:

  • Hypersensitivity to norepinephrine
  • Hypertension
  • Tachycardia
  • Arrhythmias

Dosage: [Avoid self-medication]

  • Injection: 2-12 mcg/min, titrated to effect

Note: Norepinephrine is a potent medication and should only be used under the guidance of a healthcare professional.

As a neurotransmitter, norepinephrine plays a crucial role in various physiological processes. However, this description focuses on its use as a medication. If you have any questions or concerns, please consult a healthcare professional.