Disease Related

PHENOTOLAMINE

Phenotolamine is a non-selective alpha-adrenergic antagonist used to manage conditions like pheochromocytoma (a type of tumor that causes high blood pressure) and to treat severe hypertension during surgical procedures. It works by blocking alpha-adrenergic receptors, which helps to lower blood pressure and improve blood flow. Phenotolamine is typically administered intravenously and requires close monitoring to manage potential side effects, such as tachycardia or orthostatic hypotension.

Phentolamine is a medication that belongs to the class of alpha-adrenergic blockers. Here is a detailed description:

Chemical Name: 3-4-methylphenylamine

Molecular Formula: C17H19N3

Mechanism of Action:

  • Phentolamine works by blocking alpha-adrenergic receptors, causing blood vessels to dilate and increasing blood flow.

Indications:

  • Hypertension (high blood pressure)
  • Pheochromocytoma (a rare tumor of the adrenal gland)
  • Vasospasm
  • Diagnosis of pheochromocytoma

Pharmacokinetics:

  • Absorption: Rapidly absorbed after oral or intravenous administration
  • Distribution: Widely distributed throughout the body
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted in the urine

Side Effects:

  • Hypotension (low blood pressure)
  • Tachycardia (rapid heart rate)
  • Nausea and vomiting
  • Headache
  • Fatigue

Contraindications:

  • Hypersensitivity to Phentolamine
  • Coronary artery disease
  • Heart failure
  • Liver disease

Dosage: avoid self medication

  • Oral: 5-20 mg, every 4-6 hours
  • Intravenous: 1-5 mg, every 1-2 hours

Forms:

  • Tablets
  • Injection

Please note that this information is not a substitute for medical advice. If you have any questions or concerns about Phentolamine or any other medication, please consult a healthcare professional.