PHENOXYBENZAMINE

Phenoxybenzamine is a non-selective, irreversible alpha-adrenergic antagonist used primarily to manage symptoms of pheochromocytoma, a tumor of the adrenal gland that causes excessive production of catecholamines, leading to high blood pressure. By permanently blocking alpha-adrenergic receptors, Phenoxybenzamine helps to reduce blood pressure and alleviate related symptoms. It is typically administered orally and requires careful monitoring for side effects such as orthostatic hypotension, tachycardia, or dizziness.

Phenoxybenzamine is a medication that belongs to the class of alpha-adrenergic blockers. Here is a detailed description:

Chemical Name: N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzene-1,2-diamine

Molecular Formula: C18H22ClN3O

Mechanism of Action:

Phenoxybenzamine works by blocking alpha-adrenergic receptors, causing blood vessels to dilate and increasing blood flow.

Indications:

Pheochromocytoma (a rare tumor of the adrenal gland)
Hypertension (high blood pressure)
Vasospasm
Raynaud’s disease

Pharmacokinetics:

Absorption: Well absorbed after oral administration
Distribution: Widely distributed throughout the body
Metabolism: Metabolized in the liver
Excretion: Excreted in the urine

Side Effects:

Orthostatic hypotension (low blood pressure when standing)
Dizziness
Nausea and vomiting
Headache
Fatigue

Contraindications:

Hypersensitivity to Phenoxybenzamine
Coronary artery disease
Heart failure
Liver disease

Dosage: avoid self medication

Oral: 10-20 mg, every 8-12 hours

Forms:

Capsules

Please note that this information is not a substitute for medical advice. If you have any questions or concerns about Phenoxybenzamine or any other medication, please consult a healthcare professional.